San Francisco 49ers vs Indianapolis Colts Tips - NFL Week 16
- San Francisco 49ers at Indianapolis Colts Expert NFL Tips for Week 16
- Kick Off is at 12:15 PM AEDT at Lucas Oil Stadium
- 49ers enter Week 16 with 4 consecutive wins & high-scoring games.
- Colts struggle with offense, scoring under 20 in recent matches.
- Betting tips favor 49ers, expect Purdy's passing to be key.
San Francisco 49ers fans cheer. (Photo by Aaron M. Sprecher/Getty Images)
San Francisco 49ers vs Indianapolis Colts NFL Week 16 Tips & Predictions
The San Francisco 49ers head indoors to face the Indianapolis Colts in Week 16, knowing another win would all but lock in January football. Kick-off is scheduled for 12:15pm AEDT at Lucas Oil Stadium, where the Colts are fighting to stay relevant after a dramatic mid-season collapse.
- San Francisco 49ers vs Indianapolis Colts NFL Week 16 Tips & Predictions
- Match Details: San Francisco 49ers vs Indianapolis Colts
- Best Betting Tips - 49ers vs Colts
- San Francisco 49ers -6 (Line Bet)
- Colts Under 20.5 Team Total
- Brock Purdy Over 243.5 Passing Yards
- George Kittle Anytime Touchdown
- Key Matchup to Watch
- Head-to-Head Record
- San Francisco 49ers vs Indianapolis Colts Frequently Asked Questions
San Francisco arrive red-hot, winners of four straight and averaging more than 30 points per game during that stretch. Indianapolis, meanwhile, have lost four consecutive matches and failed to score more than 20 points in any of them, with offensive instability now defining their season.
Match Details: San Francisco 49ers vs Indianapolis Colts
- Competition: NFL 2025 - Week 16
- Match: San Francisco 49ers vs Indianapolis Colts
- Date: Sunday, 21 December 2025
- Kick-off: 12:15 PM AEDT
- Venue: Lucas Oil Stadium
Best Betting Tips - 49ers vs Colts
San Francisco 49ers -6 (Line Bet)
San Francisco’s offence is clicking at exactly the right time, and they now face a Colts defence ranked 31st against the pass. Brock Purdy has punished vulnerable secondaries all season, and with Indy struggling to sustain drives, this shapes as a game where the Niners can build scoreboard pressure quickly.
Colts Under 20.5 Team Total
Indianapolis haven’t scored more than 20 points in four straight games and now face a disciplined 49ers defence that thrives on limiting red-zone efficiency. With their quarterback situation unsettled, it’s hard to see where sustained scoring comes from.
Brock Purdy Over 243.5 Passing Yards
Purdy has averaged nearly 280 yards per game over the past month and shredded Tennessee for 295 yards last week. Against the league’s worst pass defence, volume and efficiency should once again work in his favour.
George Kittle Anytime Touchdown
Kittle remains a focal point in the red zone, commanding roughly 20% of Purdy’s red-zone targets. Against a Colts defence that struggles with tight ends and middle-of-field coverage, this is a high-probability scoring angle.
Key Matchup to Watch
Colts Pass Defence vs 49ers Skill Players
Indianapolis can defend the run but collapse quickly when forced to cover multiple passing threats. With Brandon Aiyuk, Deebo Samuel and Kittle all demanding attention, mismatches are inevitable, particularly inside the red zone.
Head-to-Head Record
All-Time Record: Indianapolis Colts lead 27–18
Last Meeting:
24/10/2021 - Indianapolis 30 def San Francisco 18
San Francisco 49ers vs Indianapolis Colts Frequently Asked Questions
What time does San Francisco 49ers vs Indianapolis Colts start?
Kickoff between San Francisco 49ers vs Indianapolis Colts is at 12:15 PM AEDT, Tuesday
What channel is San Francisco 49ers vs Indianapolis Colts on?
You can watch San Francisco 49ers vs Indianapolis Colts on DAZN
Verdict
This matchup heavily favours San Francisco. The 49ers are peaking, while the Colts are simply trying to hang on. Expect Purdy to control the game through the air and San Francisco to pull away comfortably.
SF 49ers -6
Line
@9/10 - 2 Units
Pandabet
It's Black & White
The Pandabet.com.au code is BETSAUS. 18+. T&Cs apply.
Colts Under 20.5
Team Total
@7/11 - 2 Units
Lightning fast betting
Join with code BETSAU
18+. T&Cs apply
B Purdy over 243.5
Passing Yards
@9/10 - 2 Units
Use Easyform
The Ultimate Form Guide
18+ only. Gamble Responsibly. T&Cs apply
G Kittle
Anytime Touchdown
@23/20 - 1 Unit
Download the dabble app
with referral code BETSAU
Download the dabble app, enter referral code BETSAU to enjoy Dabble, the betting app with a difference! Bet as normal with & also be part of Australia's betting community where you can follow punters and sports stars, copy their bets, have banter with your mates & watch Sky Racing channels. 18+. T&Cs apply. What are you prepared to lose today? Set a deposit limit.
Top Betting Sites
Betting offers
Upcoming Events
20 December 2025
- Sydney Thunder vs Sydney Sixers -
- Cricket
21 December 2025
- JAX Jaguars @ DEN Broncos -
- NFL
23 December 2025
- SF 49ers @ IND Colts -
- NFL
Load More
SF 49ers @ IND Colts
days
hours
min
